RESUMO
The generation of cell blocks (CBs) obtained from ultrasound-guided fine needle aspiration biopsies (USFNAB) is a well-established technique in breast and thyroid pathology, but is rarely used in dermatology. We reviewed CBs obtained from USFNAB of skin lesions, which were categorized as malignant skin tumors, benign skin tumors, inflammatory skin tumors or deposit skin diseases. The diagnostic yield of each category was compared to histopathology. The USFNAB of 51 skin lesions was processed into CBs. There was overall agreement between histopathology and CBs in 84.31% of cases. Diagnostic group concordance for benign, malignant as well as inflammatory and deposit skin lesions were 69.2%, 93.7% and 86.3% respectively. Cell block generation from USFNAB aspirates of skin lesions should be considered as part of the dermatologic diagnostic armamentarium. Further experience is needed to better understand for which types of dermatologic lesions it would be clearly indicated.
Assuntos
Biópsia Guiada por Imagem , Neoplasias Cutâneas , Humanos , Biópsia por Agulha Fina , Ultrassonografia , Ultrassonografia de Intervenção , Neoplasias Cutâneas/diagnóstico por imagem , Estudos RetrospectivosRESUMO
The generation of cell blocks (CB) obtained from ultrasound-guided fine needle aspiration biopsies (USFNAB) is a well-established technique in breast and thyroid pathology, but is rarely used in dermatology. We reviewed CBs obtained from USFNAB of skin lesions, which were categorized as malignant skin tumors, benign skin tumors, inflammatory skin tumors or deposit skin diseases. The diagnostic yield of each category was compared to histopathology. The USFNAB of 51 skin lesions was processed into CBs. There was overall agreement between histopathology and CBs in 84.31% of cases. Diagnostic group concordance for benign, malignant as well as inflammatory and deposit skin lesions were 69.2%, 93.7% and 86.3% respectively. Cell block generation from USFNAB aspirates of skin lesions should be considered as part of the dermatologic diagnostic armamentarium. Further experience is needed to better understand for which types of dermatologic lesions it would be clearly indicated.
Assuntos
Biópsia Guiada por Imagem , Neoplasias Cutâneas , Humanos , Biópsia por Agulha Fina , Ultrassonografia , Ultrassonografia de Intervenção , Neoplasias Cutâneas/diagnóstico por imagem , Estudos RetrospectivosAssuntos
Hemangioma Capilar , Hemangioma , Adulto , Eritema/etiologia , Hemangioma/diagnóstico , Humanos , LactenteRESUMO
BACKGROUND: We reviewed all cases of multiple primary melanoma diagnosed at our department over a 32-year period (1987-2019) to better characterize this subgroup of patients and develop a tailored protocol to offer them closer follow-up. METHODS: Retrospective, observational, descriptive study of patients diagnosed with multiple primary melanoma at a tertiary care hospital between January 1987 and March 2019. We collected clinical, epidemiologic, and histologic characteristics of primary and subsequent melanomas and performed a descriptive analysis. RESULTS: Thirty-one patients (15 men and 16 women) with a median age of 67years (range, 36-85years) were included. Second primary melanomas were diagnosed after a median of 2years (range, 0-4years). The median number of melanomas per patient was 2 (range, 2-6). Twenty-three of the 31 patients, 25 had 2 primary melanomas (80%), 4 had 3 melanomas (13%), and 2 patients each had 5 and 6 primary melanomas. Subsequent melanomas were less invasive than the initial primary melanomas. Median Breslow thickness was 1mm (range, 0.67-4mm) for the first primary melanoma and 0.5mm (range, 0.32-2.42mm) for subsequent melanomas. CONCLUSIONS: Subsequent melanomas are thinner than primary melanomas. We observed an increase in the number of cases of multiple primary melanoma diagnosed in the last 2years of our study. Our findings highlight the importance of close, long-term follow-up of patients.
Assuntos
Melanoma , Neoplasias Primárias Múltiplas , Neoplasias Cutâneas , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Melanoma/epidemiologia , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/epidemiologia , Estudos Retrospectivos , Neoplasias Cutâneas/epidemiologiaAssuntos
Infecções por Herpesviridae/transmissão , Imunossupressores/efeitos adversos , Transplante de Pulmão/efeitos adversos , Complicações Pós-Operatórias/etiologia , Sarcoma de Kaposi/etiologia , Neoplasias Torácicas/etiologia , Anticorpos Antivirais/sangue , Substituição de Medicamentos , Eritema/etiologia , Everolimo/uso terapêutico , Herpesvirus Humano 8/imunologia , Herpesvirus Humano 8/isolamento & purificação , Humanos , Masculino , Pessoa de Meia-Idade , Ácido Micofenólico/efeitos adversos , Ácido Micofenólico/uso terapêutico , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/virologia , Sarcoma de Kaposi/diagnóstico , Sarcoma de Kaposi/virologia , Tacrolimo/efeitos adversos , Tacrolimo/uso terapêutico , Neoplasias Torácicas/diagnóstico , Neoplasias Torácicas/virologia , Doadores de Tecidos , Viremia/diagnóstico , Viremia/etiologiaRESUMO
Advances in our understanding of the biology and therapy of vascular anomalies have made this condition a common reason for consulting a dermatologist. In addition, multidisciplinary units have been created to manage patients with complex vascular anomalies. Although most vascular anomalies are diagnosed based on clinical findings, a thorough evaluation often requires additional imaging tests to determine the nature, extension, and prognosis of these lesions. Because it is fast and noninvasive, ultrasound is usually the first imaging test ordered. In the present review, we provide a state-of-the-art synthesis of key concepts in the ultrasound examination of vascular anomalies so that they are more accessible to clinicians and medical imaging specialists involved in the management of these lesions.
Assuntos
Dermatopatias Vasculares/diagnóstico por imagem , Ultrassonografia , Malformações Vasculares/diagnóstico por imagem , Hemangioma/diagnóstico por imagem , Humanos , Neoplasias Cutâneas/diagnóstico por imagemRESUMO
Sentinel lymph node biopsy is performed routinely in melanoma because lymph node progression has been shown to be the strongest predictor of survival. Given the proven relevance of biopsy findings in this type of skin cancer, the procedure has been extended to other skin tumors. Experience in nonmelanoma cancer is much more limited and the prognostic usefulness of biopsy results remains to be shown. This critical review of the literature on the various skin tumors in which sentinal node biopsy has been practiced discusses the usefulness of this procedure.